August 1967
Volume 6, Issue 4
Free
Articles  |   August 1967
Ascorbate Transport in Guinea Pig Eyes
Author Affiliations
  • BERNARD BECKER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine St. Louis, Mo.
Investigative Ophthalmology & Visual Science August 1967, Vol.6, 410-415. doi:
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      BERNARD BECKER; Ascorbate Transport in Guinea Pig Eyes. Invest. Ophthalmol. Vis. Sci. 1967;6(4):410-415.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Excised guinea pig ciliary body-iris preparations accumulated 14C-labeled L-ascorbate. The concentrating mechanism required glucose as well as Na+, K+, and Ca++ ions in the media and is inhibited by oiiabain, dinitrophenol, iodoacetate, cyanide, fluoride, desoxycorticosterone, and hydrocortisone. It demonstrates saturation kinetics with increasing concentrations of Lascorbate in the media and is competitively inhibited by D-isoascorbate. Ascorbate is secreted into the aqueous humor of the guinea pig's posterior chamber. By raising the plasma ascorbate level, saturation kinetics can be demonstrated.

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