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MARGUERITE A. CONSTANT; Distribution of 5,5 Dimethyl-2,4-Oxazolidinedione in Intraocular Fluids of Rabbits. IV. Distribution of Probenecid. Invest. Ophthalmol. Vis. Sci. 1967;6(5):492-497.
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The distribution of probenecid in intraocular fluids has been studied. Ammonium chloride or dichlorphenamide results in increased levels of probenecid in vitreous humor similarly but in less striking fashion as seen with DMO. After ammonium chloride at 2 hours the concentration in posterior aqueous humor exceeds that in anterior aqueous humor. At 4 hours the concentration is less in posterior aqueous humor. The loss appears to be "uphill" against a higher plasma concentration. After dichlorphenamide, the level in posterior aqueous humor remains in higher concentration than that of anterior aqueous humor. The data tend to support the previous suggestion that probenecid enters the eye and competes with the transport out of the eye of DMO; and that acidosis affects the posterior segment of the eye.
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