February 1966
Volume 5, Issue 1
Free
Articles  |   February 1966
Sorbitol Pathway Metabolites in the Diabetic Rabbit Lens
Investigative Ophthalmology & Visual Science February 1966, Vol.5, 65-74. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      JOHN F.R. KUCK; Sorbitol Pathway Metabolites in the Diabetic Rabbit Lens. Invest. Ophthalmol. Vis. Sci. 1966;5(1):65-74.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

The lenses of diabetic rabbits with an average plasma glucose of 502 ± 119 mg. per 100 ml. have 141 ± 44 mg. per 100 Gin. glucose, 81 ± 37 sorbitol, and 94±12 fructose. For a comparable level of lens glucose, the values for sorbitol and fructose in the diabetic rabbit lens are, respectively, one tenth and one half of the values found in the diabetic rat lens. This difference appears to depend primarily on relative deficiencies of TPNH and DPN in the rabbit lens, such deficiencies being enhanced by diabetes. Incubations of lens homogenates indicate a sluggish sorbitol pathway in the rabbit but such homogenates may not furnish the best evidence. Rabbit lenses develop peripheral vacuoles at much lower sorbitol levels than rat lenses, suggesting that in the diabetic rabbit lens a metabolic disturbance may be more important than osmotic effects.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×