Abstract
The clinical course and degree of disease severity in patients experiencing topical epinephrine hypersensitivity have been classified and correlated with circulating antiepinephrine antibody. The incidence of antiepinephrine antibody has also been studied in two control groups: (1) patients with other external ocular disease and (2) patients with no known ocular disease. Cross-reactivity between epinephrine, phenylephrine, and a triphenylmethane dye have been described.