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BERNARD BECKER; Intraocular Pressure Response to Topical Corticosteroids. Invest. Ophthalmol. Vis. Sci. 1965;4(2):198-205.
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The intraocular pressure response to topical betamethasone appears to be genetically determined. A study of patients with primary open-angle glaucoma, their relatives, glaucoma suspects, and volunteers shows three populations as to degree of responsiveness. It is suggested that these are the phenotypes which relate to the homozygous poor responder (nn), the heterozygous responder (ng), and the homozygous greater responder (gg).
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