April 1965
Volume 4, Issue 2
Free
Articles  |   April 1965
The Effect of Ouabain on the Hydration of the Cornea
Author Affiliations
  • STUART I. BROWN
    Comeal Research Unit, Institute of Biological and Medical Sciences, Retina Foundation, Boston, Mass.
  • BENGT O. HEDBYS
    Comeal Research Unit, Institute of Biological and Medical Sciences, Retina Foundation, Boston, Mass.
Investigative Ophthalmology & Visual Science April 1965, Vol.4, 216-221. doi:https://doi.org/
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      STUART I. BROWN, BENGT O. HEDBYS; The Effect of Ouabain on the Hydration of the Cornea. Invest. Ophthalmol. Vis. Sci. 1965;4(2):216-221. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of ouabain on the hydration of the rabbit cornea has been studied. The glycoside was found to prevent the dehydration of the cornea during temperature reversal procedures and its application to the cornea in vivo results in significant corned, swelling. A comparison of the effect of ouabain on the cornea to the drug's effect on electrolyte transport systems in the tissues suggests that the cornea regulates its hydration by a transport of electrolytes, presumably across the endothelium.

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