February 1964
Volume 3, Issue 1
Free
Articles  |   February 1964
The Response of the Cornea to Implantation of Polyvinyl Alcohol Sponge
Author Affiliations
  • SEYMOUR ZIGMAN
    University of Rochester, Strong Memorial Hospital, Rochester, N. Y.; Departments of Ophthalmology and Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.
  • BLENDA CARLSSON
    University of Rochester, Strong Memorial Hospital, Rochester, N. Y.
  • WILLIAM STONE, Jr
    University of Rochester, Strong Memorial Hospital, Rochester, N. Y.
Investigative Ophthalmology & Visual Science February 1964, Vol.3, 68-76. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      SEYMOUR ZIGMAN, BLENDA CARLSSON, WILLIAM STONE; The Response of the Cornea to Implantation of Polyvinyl Alcohol Sponge. Invest. Ophthalmol. Vis. Sci. 1964;3(1):68-76.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
This content is PDF only. Please click on the PDF icon to access.
Abstract

When discs of polyvinyl alcohol sponge were implanted into the corneas of rabbits, they were completely infiltrated by granulation tissue during a 5 week period. Approximately 30 mg. of new tissue was formed during this time. The new tissue, rich in both fibroblasts and collagen, was considered to be regenerating stromal tissue, and appeared to be opaque.

The content and rate of turnover of the nucleic acids of this newly formed tissue were considerably higher than those of normal stromal tissue, as would be expected for a more cellular tissue. Epithelial nucleic acid content and turnover rate, however, still exceeded those of the regenerating tissue.

Use of the method outlined will make it possible to obtain sufficient quantities of easily isolated regenerating tissue from the stroma for biochemical studies of stromal regeneration.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×