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SEYMOUR ZIGMAN, BLENDA CARLSSON, WILLIAM STONE; The Response of the Cornea to Implantation of Polyvinyl Alcohol Sponge. Invest. Ophthalmol. Vis. Sci. 1964;3(1):68-76.
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When discs of polyvinyl alcohol sponge were implanted into the corneas of rabbits, they were completely infiltrated by granulation tissue during a 5 week period. Approximately 30 mg. of new tissue was formed during this time. The new tissue, rich in both fibroblasts and collagen, was considered to be regenerating stromal tissue, and appeared to be opaque.
The content and rate of turnover of the nucleic acids of this newly formed tissue were considerably higher than those of normal stromal tissue, as would be expected for a more cellular tissue. Epithelial nucleic acid content and turnover rate, however, still exceeded those of the regenerating tissue.
Use of the method outlined will make it possible to obtain sufficient quantities of easily isolated regenerating tissue from the stroma for biochemical studies of stromal regeneration.
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