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K. DYSTER-AAS, C. E. T. KRAKAU; Aqueous flow Determination in the Rabbit by means of a Minimal Eye Trauma. Invest. Ophthalmol. Vis. Sci. 1964;3(2):127-134.
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By means of a slight trauma (infra-red light) to the iris, an increase of the flare in the anterior chamber of the eye is provoked. Its maximum occurs after about 20 minutes. The intensity is then slowly reduced to normal values.
The flare decline curve can be utilized for determination of the aqueous flow, provided that flow and permeability have regained normal values while the flare intensity is still markedly increased. That this is actually the case, 2 to 2.5 hours after the trauma, is shown by (1) injection of fluorescein, intravenously, which gives fluorescein curves of very similar shape and magnitude in both eyes (if the time between injection and trauma is more than 2 to 2.5 hours), and (2) the flare decline curve which closely follows an exponential curve. No other trend in the flow values during the course of dilution can be traced. A mean flow value of 1.1 per cent of the chamber volume per minute in a group of 12 rabbits has been determined.
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