April 1964
Volume 3, Issue 2
Free
Articles  |   April 1964
The Trabecular Effect of Noradrenalin in the Rabbit Eye
Author Affiliations
  • M. L. SEARS
    Department of Surgery, Section of Ophthalmology, School of Medicine, Yale University, New Haven, Conn.
  • T. E. SHERK
    Department of Surgery, Section of Ophthalmology, School of Medicine, Yale University, New Haven, Conn.
Investigative Ophthalmology & Visual Science April 1964, Vol.3, 157-163. doi:https://doi.org/
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      M. L. SEARS, T. E. SHERK; The Trabecular Effect of Noradrenalin in the Rabbit Eye. Invest. Ophthalmol. Vis. Sci. 1964;3(2):157-163. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Adrenergic effects upon aqueous outflow facility of the rabbit eye have been investigated with a constant rate infusion technique. Unilateral cervical ganglionectomy was performed one week prior to study, and a supersensitive response to noradrenalin was obtained. Millimicrogram doses could then be used to study the increase in outflow facility after subconjunctival, intracameral, and intravitreous noradrenalin injections. The increase in outflow facility was greatest after intracameral injection, but there were significant facility increases after subconjunctival injection at levels which did not dilate the highly supersensitive iris. The results indicate that the rabbit outflow channels can be made supersensitive to noradrenalin and that the site of action of noradrenalin on outflow facility is probably intrascleral.

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