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FRANK M. Polack, ANDREW DE ROETTH; Effect of Freezing on the Ciliary Body (Cyclocryotherapy). Invest. Ophthalmol. Vis. Sci. 1964;3(2):164-170. doi: https://doi.org/.
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Freezing of several areas of the ciliary body of normal rabbit eyes was done with a cryocautery. Tonogaphic tracings were performed before and from 6 to 8 weeks after freezing. It was observed that the average intraocular pressure of these rabbit eyes had decreased from 18 to 14 mm. Hg, the coefficient of outflow facility (C) was reduced from 0.24 to 0.17, and aqueous flow (F) was decreased from 2.26 to 1.06. Histologic observations showed an immediate postfreezing stage of edema, exudates, and hemorrhages, with destruction of cellular elements. The histologic structure of the frozen area regenerated rapidly, acquiring an almost normal appearance one week after freezing. Hyalinization of connective tissue around vessels and in the subepithelial area was observed in sections of eyes 5 to 10 weeks after freezing. It seemed apparent that these changes might be partially responsible for the decreased secretion of aqueous.
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