December 1963
Volume 2, Issue 6
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Articles  |   December 1963
Effect of IUDR and Amethopterin on Experimental Herpes Simplex Keratitis
Author Affiliations
  • MARTIN E. CORWIN
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.; Ophthalmic Microbiology, Francis I. Proctor Foundation for Research in Ophthalmology BT 802 (Cl), National Institute of Neurological Diseases and Blindness
  • VIRGINIA COLEMAN
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.
  • SIDNEY RIEGELMAN
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.
  • MASAO OKUMOTO
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.
  • ERNEST JATVETZ
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.
  • PHILLIPS THYGESON
    Departments of Ophthalmology and Microbiology, the Francis I. Proctor Foundation for Research in Ophthalmology, and School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, Calif.
Investigative Ophthalmology & Visual Science December 1963, Vol.2, 578-583. doi:https://doi.org/
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      MARTIN E. CORWIN, VIRGINIA COLEMAN, SIDNEY RIEGELMAN, MASAO OKUMOTO, ERNEST JATVETZ, PHILLIPS THYGESON; Effect of IUDR and Amethopterin on Experimental Herpes Simplex Keratitis. Invest. Ophthalmol. Vis. Sci. 1963;2(6):578-583. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The antimetabolite, 5-iodo-2'-deoxyuridine (IUDR), altered significantly the normal course of herpes simplex keratitis in rabbits when given every 2 hours during the day (8:00 A.M. to 4:00 P.M.) for 2 days only.

In qualitative experiments, virus was recovered as regularly from herpes simplex virus-infected rabbits receiving IUDR as from control rabbits. In a quantitative experiment performed on a few rabbits, virus toas recovered in the same titer from IUDR-treated rabbits as from control rabbits for the first 2 days of therapy. Not until the third day was a lower titer observed, in the IUDR-treated rabbits.

The addition of amethopterin did not alter the clinical picture, course of the experimental disease, or the virus recovery rate from herpes-infected rabbits.

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