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MARTIN E. CORWIN, VIRGINIA COLEMAN, SIDNEY RIEGELMAN, MASAO OKUMOTO, ERNEST JATVETZ, PHILLIPS THYGESON; Effect of IUDR and Amethopterin on Experimental Herpes Simplex Keratitis. Invest. Ophthalmol. Vis. Sci. 1963;2(6):578-583. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The antimetabolite, 5-iodo-2'-deoxyuridine (IUDR), altered significantly the normal course of herpes simplex keratitis in rabbits when given every 2 hours during the day (8:00 A.M. to 4:00 P.M.) for 2 days only.
In qualitative experiments, virus was recovered as regularly from herpes simplex virus-infected rabbits receiving IUDR as from control rabbits. In a quantitative experiment performed on a few rabbits, virus toas recovered in the same titer from IUDR-treated rabbits as from control rabbits for the first 2 days of therapy. Not until the third day was a lower titer observed, in the IUDR-treated rabbits.
The addition of amethopterin did not alter the clinical picture, course of the experimental disease, or the virus recovery rate from herpes-infected rabbits.
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