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HERBERT E. KAUFMAN, GEORGE M. HOWARD; Therapy of Experimental Herpes Simplex Keratitis. Invest. Ophthalmol. Vis. Sci. 1962;1(4):561-564.
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Topical therapy with trypsin, chymotrypsin, and monoxychloroserene, and corneal scrub with iodine, ether, and silver nitrate did not demonstrably reduce the incidence of a positive virus culture from rabbit corneas infected with herpes simplex. It is suggested that the virucidal properties of such substances as measured by their effect on cell-free virus suspensions is not pertinent to the abolition of infection from primary experimental dendritic keratitis, and may not be an important consideration in the therapy of this condition.
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