October 1962
Volume 1, Issue 5
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Articles  |   October 1962
Effects of Triethylenethiophosphoramide on the Carrageenin Granuloma of the Guinea Pig Cornea
Author Affiliations
  • ROBERT P. BURNS
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore.
  • RICHARD BEIGHLE
    John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore.; Recipient of Fight-for.Sight Summer Student Fellowship, SF 187 (C2), from the National Council to Combat Blindness, Inc., New York, N. Y.
Investigative Ophthalmology & Visual Science October 1962, Vol.1, 666-671. doi:
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      ROBERT P. BURNS, RICHARD BEIGHLE; Effects of Triethylenethiophosphoramide on the Carrageenin Granuloma of the Guinea Pig Cornea. Invest. Ophthalmol. Vis. Sci. 1962;1(5):666-671.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The carrageenin granuloma of the guinea pig cornea is an excellent tool to use in controlled study of new therapeutic agents. In vascularization of the guinea pig cornea induced by the carrageenin granuloma, selected levels of dosage of triethylenethiophosphoramide applied, locally or subconjunctivally were found to inhibit growth of blood vessels into the cornea. This inhibition of vascularization was only temporary and was accompanied by prolongation of corneal opacity and toxic side effects.

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