October 1962
Volume 1, Issue 5
Articles  |   October 1962
Immune Corneal Rings
Author Affiliations
    Department of Research, Wills Eye Hospital, Philadelphia, Pa.
    Department of Research, Wills Eye Hospital, Philadelphia, Pa.; Present address, University of Lausanne School of Medicine, Switzerland.
    Department of Research, Wills Eye Hospital, Philadelphia, Pa.
Investigative Ophthalmology & Visual Science October 1962, Vol.1, 672-685. doi:
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      THEODORE W. SERY, ALEXANDER H. PINKES, ROSE MARIE NAGY; Immune Corneal Rings . Invest. Ophthalmol. Vis. Sci. 1962;1(5):672-685.

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      © ARVO (1962-2015); The Authors (2016-present)

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Ring reactions of the cornea have been given a new nomenclature based upon their mechanism of formation. The term immune corneal ring includes all types and distinguishes ring reactions from the general term, "anaphylactic" keratitis. The systemic immune ring, arising slowly from serum antibody aiul cells at the limbus, is distinguished from the local immune ring, which rapidly develops at the "target site" of injection. The former type develops from a single corneal injection, whereas the latter is dependent upon at least one reinjection of antigen andappears to begin independently of systemic immunity. A local tissue antibody of as yet undetermined origin is postulated to stimulate the formation of local immune rings. The origin of the cellular component of local rings is still undecided. Systemic immune rings which are another manifestation of the Wessely phenomenon and which normally develop about 2 weeks after sensitization will usually develop within 6 or 7 days in animals previously sensitized systemically; the accelerated reaction can occur as early as 1 day after challenge. Reactions that develop in 1 or 2 days after intracorneal challenge can occur in the absence of demonstrable corneal vascularization. A delayed hypersensitivity component is postulated to account for the tissue damage observed in some of the corneas. The importance of the breed of rabbit used in this type of study is emphasized.


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