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Blanca Ferrandez, Antonio Ferreras, Pilar Calvo, Beatriz Abadia, Paolo Fogagnolo, Yaowu Wang, Jose M. Marin, Michele Iester; Retinal Sensitivity Is Reduced in Patients With Obstructive Sleep Apnea. Invest. Ophthalmol. Vis. Sci. 2014;55(11):7119-7125. doi: 10.1167/iovs.14-14389.
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To evaluate the outcomes of standard automated perimetry (SAP) in patients with obstructive sleep apnea (OSA).
Eighty OSA patients and 111 age-matched controls were consecutively and prospectively enrolled. One eye per subject was randomly selected. All participants underwent at least one reliable SAP (24-2 SITA Standard algorithm). The peripapillary retinal nerve fiber layer thickness (RNFL) was measured with spectral-domain optical coherence tomography (OCT). Patients with OSA were classified into three groups according to the apnea/hypopnea index: mild, moderate, or severe OSA. Parameters of SAP and OCT were compared between healthy controls and OSA patients. Correlation of apnea/hypopnea index with OCT and SAP measurements were calculated.
Mean age, best-corrected visual acuity, and central corneal thickness were similar between groups. Intraocular pressure, however, was lower in the OSA group. Mean deviation of SAP was −0.23 ± 0.8 dB in the control group and −1.74 ± 2.8 dB in the OSA group (P < 0.001). Thickness of RNFL measured with OCT did not differ significantly between groups. Patients with OSA showed reduced sensitivity at most points tested by white-on-white perimetry compared with healthy individuals. The threshold values were more depressed in the peripheral visual field. The apnea/hypopnea index was related to the SAP indices: Pearson correlations were −0.432 with mean deviation, 0.467 with pattern standard deviation, and −0.416 with the visual field index (P < 0.001).
Patients with OSA exhibited reduced retinal sensitivity measured with SAP compared with healthy controls.
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