April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Corneal confocal microscopy following conventional, transepithelial by iontophoresis, and accelerated corneal collagen cross-linking procedures for keratoconus.
Author Affiliations & Notes
  • Nacim Bouheraoua
    CHNO XVXX, Paris, France
    Inserm UMR 968, Institut de la Vision, Paris, France
  • Lea Jouve
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Mohamed El Sanharawi
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Otman Sandali
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Patrick Loriaut
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Cyril Temstet
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Elena Basli
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Vincent Borderie
    CHNO XVXX, Paris, France
    Inserm UMR 968, Institut de la Vision, Paris, France
  • Laurent Laroche
    CHNO XVXX, Paris, France
    Pierre & Marie Curie University Paris 06, Paris, France
  • Footnotes
    Commercial Relationships Nacim Bouheraoua, None; Lea Jouve, None; Mohamed El Sanharawi, None; Otman Sandali, None; Patrick Loriaut, None; Cyril Temstet, None; Elena Basli, None; Vincent Borderie, None; Laurent Laroche, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1022. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Nacim Bouheraoua, Lea Jouve, Mohamed El Sanharawi, Otman Sandali, Patrick Loriaut, Cyril Temstet, Elena Basli, Vincent Borderie, Laurent Laroche; Corneal confocal microscopy following conventional, transepithelial by iontophoresis, and accelerated corneal collagen cross-linking procedures for keratoconus.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1022.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To compare early corneal healing following conventional, transepithelial by iontophoresis, and accelerated corneal collagen cross-linking (CXL) protocols.

Methods: Forty five patients with progressive keratoconus were divided into three groups to receive conventional, transepithelial by iontophoresis, or accelerated CXL. In vivo corneal confocal microscopy was performed on each patient preoperatively and at 1, 3, and 6 months postoperatively. Density of corneal sub-basal nerves, anterior and posterior keratocytes, and corneal endothelium were assessed.

Results: The subbasal nerve plexus was essentially obliterated immediately following conventional and accelerated CXL. The anterior stroma showed significant changes after CXL: complete obliteration of keratocytes, increased tissue reflectivity, a honey-comb like appearance, and circular lacunae. These changes were more pronounced following conventional and accelerated CXL. There were no apparent changes to the posterior stroma or endothelium.

Conclusions: In vivo corneal confocal microscopy analysis of the postoperative impact of CXL on the cornea revealed clear differences among conventional, accelerated, and transepithelial by iontophoresis CXL protocols. Conventional CXL had a greater impact on the sub-basal nerve plexus and loss of anterior stromal keratocytes in the early postoperative period. The posterior stroma and corneal endothelium were unaffected.

Keywords: 479 cornea: clinical science • 574 keratoconus • 596 microscopy: confocal/tunneling  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×