April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal Pigment Epithelial Changes on Wide-Field Fundus Autofluorescence and Swept-Source Optical Coherence Tomography Imaging After Successful Retinal Detachment Surgery
Author Affiliations & Notes
  • Kenneth Yau
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Maria Gil Martinez
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Salvador Pastor
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Yianna Antoniou
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Tsveta Ivanova
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Assad Jalil
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Jose Luis Vallejo-Garcia
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Stephen Charles
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Rita Mclaughlan
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
  • Paulo E Stanga
    Ophthalmology, Manchester Vision Regeneration (MVR) Lab at NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Manchester, United Kingdom
    Manchester Academic Health Science Centre and Centre for Ophthalmology and Vision Research, Institute of Human Development, University of Manchester, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships Kenneth Yau, None; Maria Gil Martinez, None; Salvador Pastor, None; Yianna Antoniou, None; Tsveta Ivanova, None; Assad Jalil, None; Jose Luis Vallejo-Garcia, None; Stephen Charles, None; Rita Mclaughlan, None; Paulo Stanga, Allergan plc (C), Allergan plc (R), Bausch & Lomb Inc. (C), Bausch & Lomb Inc. (F), Bausch & Lomb Inc. (R), Bayer AG (C), Bayer AG (R), Novartis AG (C), Novartis AG (R), Optos plc (C), Optos plc (F), Optos plc (R), Thrombogenics Inc. (C), Thrombogenics Inc. (R), Topcon Corp. (C), Topcon Corp. (F), Topcon Corp. (P), Topcon Corp. (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1122. doi:
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      Kenneth Yau, Maria Gil Martinez, Salvador Pastor, Yianna Antoniou, Tsveta Ivanova, Assad Jalil, Jose Luis Vallejo-Garcia, Stephen Charles, Rita Mclaughlan, Paulo E Stanga; Retinal Pigment Epithelial Changes on Wide-Field Fundus Autofluorescence and Swept-Source Optical Coherence Tomography Imaging After Successful Retinal Detachment Surgery. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1122.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To analyse retinal pigment epithelium (RPE) and neuroretinal (NR) changes on Wide-Field Fundus Autofluorescence (WF-FAF) and Swept-Source Optical Coherence Tomography (SS-OCT) imaging after succesful rhegmatogenous retinal detachment (RD) surgery.

 
Methods
 

Retrospective, non-interventional study. We analysed the images of 15 patients (8 male, 7 female) who underwent RD surgery. All patients were post-operatively imaged using wide-field colour and fundus autofluorescence (200TX®, Optos plc.) and 1,050nm SS-OCT (Atlantis Deep Range Imaging OCT1®, Topcon Inc.). All images were analysed by two independent observers.

 
Results
 

Mean age was 59 years (Range: 26-82). The macula was preoperatively detached in 8 eyes and attached in 7. Eleven patients (73%) underwent 23G pars plana vitrectomy (PPV) surgery with endolaser and intraocular injection of gas; cryotherapy was also used in 6 (55%) of these patients. Four patients (27%) underwent cryobuckle surgery. Post-operative vision improved in all patients. Reported post-operative sympthoms were: metamorphopsia (1) and central blurred vision (8). Macular relative hypo-fluorescence was present postoperatively in 4 patients with pre-operative macula OFF RD and postoperative blurred vision and in 1 patient with pre-operative macular ON and post-operative improvement of vision. Relative macular hyper-autofluorescence was present postoperatively in 9 patients . A pattern of “patchy” relative autofluorescence was present in one eye with postoperative metamorphopsia. SS-OCT showed discontinuation at the junction of the inner and outer sgment of the photoreceptor (IS-OS) line in 7 patients. (SEE TABLE)

 
Conclusions
 

Wide-Field Fundus Autofluorescence and Swept-Source OCT imaging following RD surgery can be useful for evaluating RPE function and changes in the neuroretina, thus explaining visual outcome. Further studies are required to look for pre-operative markers of post-operative improvement in vision.

  
Keywords: 550 imaging/image analysis: clinical • 701 retinal pigment epithelium • 697 retinal detachment  
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