April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Early retinal toxicity diagnosis by OCT in patients under Chloroquine or Hydroxichloroquine treatment
Author Affiliations & Notes
  • Claudia Recillas-Gispert
    Ophthalmology, INCMNSZ, Mexico City, Mexico
  • Arturo Macias
    Ophthalmology, INCMNSZ, Mexico City, Mexico
  • Veronica De Leon
    Ophthalmology, INCMNSZ, Mexico City, Mexico
  • Footnotes
    Commercial Relationships Claudia Recillas-Gispert, None; Arturo Macias, None; Veronica De Leon, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1138. doi:
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      Claudia Recillas-Gispert, Arturo Macias, Veronica De Leon; Early retinal toxicity diagnosis by OCT in patients under Chloroquine or Hydroxichloroquine treatment. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1138.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To evaluate OCT findings in patients under Chloroquine or Hydroxichloroquine treatment

Methods: We performed macular OCT (Optovue RtVue Fourier-Domain Ocular Coherence Tomography) in 75 patients under treatment with Chloroquine or Hydroxichloroquine. All patients underwent a complete ophthalmological examination with color vision Ishihara test, macular visual field and fluoresceína angiography. Variables measured were age, gender, systemic diagnosis, antimalarial drugs intake time and total cumulative dose.

Results: A total of 75 patients (150 eyes) were studied; 70 females and 5 males, with an average age of 48 years-old (range: 19-76), the most common disease diagnosis was rheumathoid arthritis followed by systemic lupus erythematosus, with an average of 15.86 years since disease diagnosis. Antimalaric intake time was 8 years with a cumultive dose of 602gr. Fundus examination findings were normal except for patients with severe toxicity. Most of the patients showed a ring pattern of parafoveal thinning with an average central macular thickness of 239. Fluorescein angiography an 10-2 automated visual field were normal in the majority of patients.

Conclusions: OCT may be an useful tool for chloroquine or hydroxichloroquine retinal toxicity screening with a characteristic ring pattern of macular thinning. These findings are present in most of the cases before other clinical or ancillary test alterations.

Keywords: 620 ocular irritancy/toxicity testing • 462 clinical (human) or epidemiologic studies: outcomes/complications • 550 imaging/image analysis: clinical  

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