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Ying Zhu, Keyan Wang, Gezhi Xu; The prognostic value of multifocal electroretinogram and optical coherence tomography in panretinal photocoagulation. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1140.
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To investigate the prognostic value of multi-focal electroretinography (mfERG) and optical coherence tomography (OCT) in diabetic eyes receiving pan-retinal photocoagulation (PRP).
Patients with severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) who needed PRP were included in this study. MfERG and OCT data were recorded before PRP while the final best corrected visual acuity (BCVA) was recorded at 6 months after PRP. The 1-3-6mm ETDRS macular grid was superimposed over the mfERG hexagonal pattern (Figure 1). For each area of the 9 sectors, the responses from the corresponding hexagons were summed for analysis. Correlations between pre-PRP data and post-PRP BCVA were analyzed with Pearson’s correlation analysis and multivariate linear regression analysis.
Among the 42 eyes included in this study, 31 eyes (73.8%) showed improvement or remained stable in visual acuity while 11 eyes (26.2%) showed deterioration in BCVA. The final BCVA was significantly correlated with the amplitude and latency of mfERG in all nine sectors and the amplitude had a stronger correlation than the latency. The foveal IS/OS and ELM status, as well as retinal t
A lower amplitude of mfERG and disrupted foveal IS/OS status were significantly correlated with worse visual prognosis in diabetic eyes after PRP.
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