April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Relationship with Vision and Characteristics of X-linked Juvenile Retinoschisis in Fourier Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Joo Yong Lee
    Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea
  • Hyun Seung Yang
    Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea
  • Jung Bok Lee
    Statistics, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea
  • Young Hee Yoon
    Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea
  • June-Gone Kim
    Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Joo Yong Lee, Bausch & Lomb South Asia Inc (C); Hyun Seung Yang, None; Jung Bok Lee, None; Young Hee Yoon, None; June-Gone Kim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1142. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Joo Yong Lee, Hyun Seung Yang, Jung Bok Lee, Young Hee Yoon, June-Gone Kim; Relationship with Vision and Characteristics of X-linked Juvenile Retinoschisis in Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1142.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To investigate the tomographic characteristics of the outer retina and choroid and their relationship with visual prognosis in X-linked juvenile retinoschisis (XLRS) patients with Fourier-Domain optical coherence tomography (FD-OCT).

 
Methods
 

We analyzed 20 consecutive eyes with XLRS using FD-OCT, retrospectively. The clinical and tomographic features of the outer retina,including the external limiting membrane (ELM), inner segment/outer segment (IS/OS) junction,cone cell outer segment tips (COST) line, photoreceptor outer segment (PROS) length, and choroid,were evaluated. To better analyze choroidal thickness and PROS length, 40 age-, sex-, and refraction-matched healthy eyes (1:2 matched linear mixed model) were randomly selected.

 
Results
 

The most prevalent area of abnormality in the outer retina layer was the outer plexiform layer (OPL; 60%) and COST line (75%). On average, the subfoveal choroid and PROS lengths were~35 µm thicker and ~25µm thinner, respectively,in XLRS patients (P= .084 and P<.001, respectively).A dominant IS/OS junction,COST line defects, and PROS length were related to patient BCVA (P =.029, P<.001, and P<.001, respectively) in univariate analysis. Outer nuclear layer schisis and PROS length were the only factors related to BCVA in multivariate analysis (P =.029 and 0.020, respectively).

 
Conclusions
 

OPL and photoreceptor microstructure defects were frequently observed in XLRS patients. In addition, outer nuclear layer defects and shortened PROS length as well as photoreceptor microstructure defects may be closely related to poor vision in XLRS.

 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 696 retinal degenerations: hereditary  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×