April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Anti-histamine receptor h4 treatment reduced choroidal neovascularization independent of vascular endothelial growth factor
Author Affiliations & Notes
  • Ryo Ijima
    Ophthalmology, Nagoya Univ Grad School of Med, Nagoya, Japan
  • Hiroki Kaneko
    Ophthalmology, Nagoya Univ Grad School of Med, Nagoya, Japan
  • Fuxiang Ye
    Ophthalmology, Nagoya Univ Grad School of Med, Nagoya, Japan
  • Shu Kachi
    Ophthalmology, Nagoya Univ Grad School of Med, Nagoya, Japan
  • Hiroko Terasaki
    Ophthalmology, Nagoya Univ Grad School of Med, Nagoya, Japan
  • Footnotes
    Commercial Relationships Ryo Ijima, None; Hiroki Kaneko, None; Fuxiang Ye, None; Shu Kachi, None; Hiroko Terasaki, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1193. doi:
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    • Get Citation

      Ryo Ijima, Hiroki Kaneko, Fuxiang Ye, Shu Kachi, Hiroko Terasaki; Anti-histamine receptor h4 treatment reduced choroidal neovascularization independent of vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1193.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To examine the relationship between vascular endothelial growth factor (Vegf) and histamine receptor h4 (Hrh4) for the treatment of choroidal neovascularization (CNV) in mice.

Methods: In wild-type and Hrh4-/- mice, laser photocoagulation was performed in the retina to induce experimental CNV (laser-CNV). Protein expressions of Vegf were examined and CNV volumes were measured in mice after inducing laser-CNV. Anti-Vegf neutralizing antibody (1μg) or isotype IgG control combined with JNJ7777120 (1μg), Hrh4 antagonist, was injected intravitreously after inducing laser-CNV, and CNV volumes were compared.

Results: Laser-CNV volume in Hrh4-/- mice was significantly smaller than that in wild-type mice. However, mouse Vegf level in wild-type mice RPE 3 days after laser-photocoagulation was not significantly different from that in Hrh4-/- mice. Anti-VEGF neutralizing antibody mixed with JNJ7777120 significantly reduced CNV volume in wild-type mice compared to isotype IgG antibody mixed with JNJ7777120.

Conclusions: CNV is suppressed by Hrh4 reduction via Vegf-independent mechanism.

Keywords: 453 choroid: neovascularization  
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