April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
A Comparative Study of the Water Drinking Test in Eyes with Open-Angle Glaucoma and Prior Trabeculectomy or Tube Shunt
Author Affiliations & Notes
  • Patricia Martinez
    Glaucoma, Wills Eye Hospital, Philadelphia, PA
  • Valerie Trubnik
    Glaucoma, Wills Eye Hospital, Philadelphia, PA
  • Benjamin Leiby
    Pharmacology and Experimental Therapeutics Division of Biostatistics, Jefferson University/Jefferson Medical college, Philadelphia, PA
  • Sarah Hegarty
    Pharmacology and Experimental Therapeutics Division of Biostatistics, Jefferson University/Jefferson Medical college, Philadelphia, PA
  • Jonathan S Myers
    Glaucoma, Wills Eye Hospital, Philadelphia, PA
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 125. doi:
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      Patricia Martinez, Valerie Trubnik, Benjamin Leiby, Sarah Hegarty, Jonathan S Myers; A Comparative Study of the Water Drinking Test in Eyes with Open-Angle Glaucoma and Prior Trabeculectomy or Tube Shunt. Invest. Ophthalmol. Vis. Sci. 2014;55(13):125.

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Abstract
 
Purpose
 

To compare the intraocular pressure (IOP) response after the water drinking test (WDT) in patients who have undergone trabeculectomy or tube shunt surgery.

 
Methods
 

We prospectively studied 40 eyes of 34 open-angle glaucoma subjects who had undergone trabeculectomy (n= 20) or tube shunt surgery (n= 20). Both groups were matched by IOP range and by number of topical antiglaucoma medications used. After a baseline IOP assessment, subjects drank 10ml water/kg body weight over 15 minutes. IOP was then measured with Goldman tonometer every 15 minutes over a one-hour period. Outcomes measures were IOP peak, fluctuation, mean and range.

 
Results
 

There were no significant differences in baseline demographics, baseline clinical characteristics or IOP changes during the WDT between the two surgical procedure groups. In the trabeculectomy and tube shunt groups, Peak IOP was 16.25±5.55 and 16.15±5.36 mmHg, respectively (P=0.8294); IOP fluctuation (IOP max- IOP baseline)was 3.95±2.17 and 3.6±2.23 mmHg (P=0.6432) and IOP range 2.78±1.56 and 2.8±1.47 mmHg (P=1.00). When IOP fluctuation associations were studied (Wilcoxon test and Multivariable linear regression), the use of systemic antihypertensive blood pressure medication was associated with approximately 2 mmHg increase in IOP fluctuation.

 
Conclusions
 

Subjects who had undergone either trabeculectomy or tube shunt surgery showed a similar IOP response to the WDT fluid challenge. Subjects using systemic blood pressure lowering medications experienced significantly higher IOP fluctuation during the test.

 
Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment • 633 outflow: trabecular meshwork  
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