April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Water-drinking test for monocular trial with prostaglandin analogue in patients with primary open angle glaucoma or ocular hypertension
Author Affiliations & Notes
  • Wendel Martins
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
    Glaucoma, Centro de Reabilitação Visual de Alagoas - CERVI, Maceió, Brazil
  • Marcelo Hatanaka
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
  • Luciana M Alencar
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
  • Wilma Lelis
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
  • Ricardo Suzuki
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
  • Isabella Landin
    Glaucoma, Centro de Reabilitação Visual de Alagoas - CERVI, Maceió, Brazil
  • Maiara Moraes
    Glaucoma, Centro de Reabilitação Visual de Alagoas - CERVI, Maceió, Brazil
  • Remo Susanna
    Glaucoma, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil
  • Footnotes
    Commercial Relationships Wendel Martins, None; Marcelo Hatanaka, None; Luciana Alencar, None; Wilma Lelis, None; Ricardo Suzuki, None; Isabella Landin, None; Maiara Moraes, None; Remo Susanna, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 126. doi:
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      Wendel Martins, Marcelo Hatanaka, Luciana M Alencar, Wilma Lelis, Ricardo Suzuki, Isabella Landin, Maiara Moraes, Remo Susanna; Water-drinking test for monocular trial with prostaglandin analogue in patients with primary open angle glaucoma or ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2014;55(13):126.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

To determine the reproducibility of the modified diurnal tension curve (mDTC) and the water-drinking test (WDT) in patients with primary open angle glaucoma or ocular hypertension submitted to monocular trial with prostaglandin analogue.

 
Methods
 

Nineteen subjects were submitted to mDTC followed by WDT in both eyes, under no treatment. Treatment with prostaglandin analogues was initiated on the same night in only one randomized eye per patient. The mDTC and WDT were repeated on the following day and after one week on the monocular trial. Intraclass correlation coefficients (ICC) were used to determine the reproducibility of mean intraocular pressure (IOP) during the mDTC and peak IOP on the WDT, and to compare treated eyes with their contralateral non-treated eyes

 
Results
 

In untreated eyes reproducibility of mean IOP was good, but higher between the two first days than after one week, with ICCs for mean mDTC IOP was 0,83 between the first two days, and 0,79 between the first test and one week later. The IOP peaks for the WDT had excellent reproducibility between the first two days (ICC = 0,97) and good reproducibility between the first test and one week later (ICC = 0,79). All ICC tests had p<0,001.

 
Conclusions
 

There was excellent level of reproducibility within one week to average and peak parameters on the untreated group. There was no statistically significant difference between Day 2 and Day 1 or Week 1 and Day 1 for the average and peak parameters on the untreated group. There was significant reduction on Day 2 and Week 1 to average and peak parameters compared to Day 1 on the treated group. There was reduction to average and peak parameters on the treated group compared to the untreated group during the same period. We conclude that it is possible to perform monocular therapeutic test with bimatoprost 0.01% in a week considering that the contralateral eye untreated group did not change throughout the study period and there was intraocular pressure reduction on the treated group compared to baseline and untreated group

  
Keywords: 466 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • 726 stress response  
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