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Jian-Huan Chen, Haoyu Chen, Weiqi Chen, Mingzhi Zhang, Chi Pui Pang; Interactive analysis of PTX3 and CRP in genetic association with polypoidal choroidal vasculopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1322. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Our previous study has indicated that long pentraxin-3 (PTX3) is associated with polypoidal choroidal vasculopathy (PCV). We investigated genetic interaction between PTX3 and its paralog c-reactive protein (CRP) in PCV.
A total of 445 unrelated subjects were recruited at Shantou, China, including 338 controls and 107 PCV patients. Three tag single nucleotide polymorphisms (SNPs) including rs1205, rs1800947 andrs1417938 in CRP were genotyped using Taqman assays. Five tag SNPs of PTX3 including rs9289983, rs2305619, rs1840680, rs3845978, and rs4680367 were from our previous study. Disease association was analyzed by logistic regression controlled for sex and age. Odds ratio (OR) was calculated accordingly.
SNP association analysis showed that none of the three CRP tag SNPs was associated with PCV (all P > 0.05). However, Significant interaction was found between CRP rs1205 and PTX3 rs9289983 (P = 0.007). The CRP rs6214 TT genotype combined with the PTX3 rs9289983 AA genotype exhibited the most prominent protective effect (OR = 0.1). The CRP rs6214 CC genotype combined with the PTX3 rs9289983 AA genotype conferred the highest risk effect (OR = 2.1). No significant interaction was found between other two CRP and PTX3 tag SNPs (all P > 0.05).
In the current study PTX3 significantly interacted with CRP in genetic association with PCV.
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