Relationship Between Microperimetry and Goldmann Visual Field Variability In Retinitis Pigmentosa

Abstract

Purpose: Reliable testing of visual sensitivity in patients with retinitis pigmentosa (RP) has been reported using both microperimetry (MP) and Goldmann perimetry (GVF) for central and peripheral visual fields respectively. However, the relationship between the two tests in evaluating changes in visual function in patients with RP has not been characterized.

Methods: Twelve participants with an established diagnosis of RP were recruited into a multicentre clinical trial assessing the efficacy of transcorneal electrical stimulation for RP (NCT01847365). Participants underwent weekly treatment of one eye, retaining the other eye as a control. Visual field testing with MP and GVF analysis was performed on both eyes at baseline and after three months. Statistical analysis was performed using Spearman rank correlation coefficient.

Results: GVF analysis demonstrated marked peripheral field constriction, typical of RP, on all participants at baseline. MP was reliably performed utilising foveal fixation at baseline. A range of defects were apparent, with most participants displaying reduced retinal sensitivity in the central 10 degrees.

Conclusions: Both MP and GVF are useful measures of visual function in patients with RP. In advanced cases, MP has the advantage of targeting specific central areas, which cannot be mapped accurately with GVF. Using both measures is more effective at monitoring changes in interventional trials and disease progression than using each test alone.

Keywords: 696 retinal degenerations: hereditary • 758 visual fields • 468 clinical research methodology