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Luiz Henrique Lima, Juliana M F Sallum, Vivienne C Greenstein, Stephen H Tsang; Progressive Expansion of the Hyperautofluorescent Ring in Cone-Rod Dystrophy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1419.
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To demonstrate progressive expansion of the hyperautofluorescent ring and changes in retinal structure in patients with cone-rod dystrophy (CRD), using fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT)
Twenty eyes of 20 CRD patients with a hyperautofluorescent ring were studied. Ring expansion was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline, 12 and 24 month follow-ups. FAF was obtained at 12 and 24 in all study eyes. SD-OCT images were obtained on all study eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 month follow-ups
The external boundaries of the ring were identified along both the horizontal axis and the vertical axis in all study eyes. Internal boundaries were identified in all study eyes. Expansion of the hyperautofluorescent ring was demonstrated in all patients. SD-OCT measurements showed a decrease in the IS/OS junction length
There was evidence of ring expansion in all CRD patients along most meridians associated with a loss of the IS/OS junction lamina temporal and nasally to the fovea. Therefore, FAF and SD-OCT may be important non-invasive imaging techniques to monitor CRD patients.
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