April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Neurotrophic keratitis induced by cocaine snorting.
Author Affiliations & Notes
  • Flavio Mantelli
    Ophthalmology, IRCCS Fondazione GB Bietti, Rome, Italy
  • Marta Sacchetti
    IRCCS Ospedale San Raffaele, Milan, Italy
  • Alessandro Lambiase
    Campus Bio-Medico University, Rome, Italy
  • Stefano Bonini
    Campus Bio-Medico University, Rome, Italy
  • Footnotes
    Commercial Relationships Flavio Mantelli, None; Marta Sacchetti, None; Alessandro Lambiase, None; Stefano Bonini, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1458. doi:
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      Flavio Mantelli, Marta Sacchetti, Alessandro Lambiase, Stefano Bonini; Neurotrophic keratitis induced by cocaine snorting.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1458.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Cocaine abuse may cause severe ischemic and necrotic tissue damage in several organs, including the eye. However, the cornea is an avascular tissue relying on sensitive nerves for its trophic support, and the pathogenesis of cocaine-induced corneal lesions is unclear. In this study we aimed to investigate if corneal sensitivity, ocular surface structures and tear function are damaged by habitual cocaine snorting.

Methods: Ocular examination, corneal sensitivity and tear function testing were carried out in 48 cocaine addicts, and in 22 heroin addicts and 30 drug-free age/sex-matched individuals who served as controls. We also performed corneal confocal microscopy, conjunctival impression cytology and tear samples' collection to evaluate corneal and conjunctival morphology, and the presence of cocaine in tears. Statistical analysis was performed to compare groups and to correlate clinical findings with anamnestic data on cocaine use.

Results: We observed decreased corneal sensitivity in 26 cocaine addicts, and 6 of them showed neurotrophic keratitis, characterized by corneal damage, absence of symptoms, reduced tear secretion, and prolonged interblink-time. No significant changes in ocular surface parameters including corneal sensitivity were observed in heroin addicts. The major risk factors for developing cocaine-induced neurotrophic keratitis appeared to be duration and frequency of drug abuse.

Conclusions: A complete ophthalmic evaluation including corneal sensitivity testing should be planned for an optimal management of cocaine addicts, even in the absence of ocular symptoms, to reduce the risk of corneal lesions and consequent vision impairment. Sensory nerve damage should also be evaluated in cocaine-induced lesions of other organs.

Keywords: 482 cornea: epithelium • 503 drug toxicity/drug effects  

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