April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
A prospective study of corneal sensation following myopic LASIK with two femtosecond lasers
Author Affiliations & Notes
  • Jennifer Kung
    Byers Eye Institute at Stanford, Palo Alto, CA
  • Edward E Manche
    Byers Eye Institute at Stanford, Palo Alto, CA
  • Footnotes
    Commercial Relationships Jennifer Kung, None; Edward Manche, AMO (F), Best Doctors, Inc. (C), Calhoun Vision, Inc. (I), Gerson Lehrmann (C), Krypton Vision, Inc. (I), Refresh Innovations, Inc. (I), Seros Medical, LLC (I), Veralas, Inc. (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1512. doi:
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    • Get Citation

      Jennifer Kung, Edward E Manche; A prospective study of corneal sensation following myopic LASIK with two femtosecond lasers. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1512.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Poor corneal sensation is a critical factor in the development of post-LASIK dry eye. The purpose of this study is to compare recovery of corneal sensation following standard versus inverted side-cut LASIK flaps. Prior studies have suggested that inverted side-cut LASIK flaps may have increased flap adhesion post-operatively for better wound healing, more stability compared to microkeratome flaps, and improved apposition of severed nerves.

Methods: 120 eyes of 60 patients underwent LASIK - one eye with a 150 kHz femtosecond laser using a 130 degree inverted side-cut and the fellow eye with a 60 kHz femtosecond laser using a conventional 70 degree side-cut. All eyes underwent wavefront-guided ablation with the AMO CustomVue S4 excimer laser. Cochet-Bonnet aesthesiometry measured corneal sensation pre-operatively and at post-operative months one, three, six and twelve.

Results: Cochet-Bonnet values were equal pre-operatively. Post-operative Cochet-Bonnet values were greater with inverted versus conventional side-cuts with means of 14.5 > 13.2 (p = 0.08) at 1 month, 24.9 > 18.4 (p < 0.01) at 3 months, 51.2 > 42.6 (p < 0.01) at 6 months, and 59.8 > 58.3 (p < 0.01) at 12 months, respectively.

Conclusions: Eyes treated with an inverted side-cut had a faster recovery of corneal sensation compared to eyes treated with a conventional side-cut.

Keywords: 683 refractive surgery: LASIK • 679 refractive surgery: comparative studies • 486 cornea: tears/tear film/dry eye  

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