Purchase this article with an account.
Karin Kofler, Christopher Schütze, Bernhard Baumann, Stefan Zotter, Philipp Ken Roberts, Michael Pircher, Markus Ritter, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Correlation between polarization sensitive optical coherence tomography and microperimetry in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1624.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Retinitis pigmentosa (RP) is a clinical and genetic heterogenic group of retinal diseases affecting rods and cones. There is also a strong involvement of the retinal pigment epithelium (RPE) in the pathophysiologic process in RP. To get new insights into the relation between this important layer and the retinal function we correlated the integrity of the RPE by using polarization sensitive optical coherence tomography (PS-OCT) with the retinal sensitivity.
Twenty-one eyes of eleven patients with RP were imaged using a prototype PS OCT device. The area of preserved retinal sensitivity (AOPRS) was evaluated by using microperimetry (Nidek MP1). Images of these two techniques were overlayed and compared. For the data analysis a grading system was developed. Eyes with a clearly overlapping RPE compared to the AOPRS were graded with 2, whereas eyes with slightly overlapping RPE were graded with 1. Eyes where the AOPRS clearly overlapped the RPE were graded with -2. Eyes with slightly overlapping AOPRS where graded with -1. The quality of RPE integrity was assessed with a scale from 1 to 3 (1 very good integrity, 3 poor quality).
In eighteen eyes the RPE overlapped the AOPRS. Thirteen eyes were graded with 2, five eyes with 1. In two eyes the AOPRS clearly overlapped the RPE and were graded with -2. In one eye the RPE on the nasal side was graded with -1 and on the temporal side with 2. In twelve eyes the integrity of the RPE inside the AOPRS was graded with 1, in eight eyes with 2 and in one eye with 3.
PS-OCT is capable of detecting the integrity of the RPE in cases of RP. This is the first study correlating RPE integrity assessed by PS-OCT and retinal sensitivity. Based on this technique and the correlation with retinal function new insight into the condition of the RPE in the progression of RP can be gained.
This PDF is available to Subscribers Only