MORPHOMETRIC AND FUNCTIONAL ASSESSMENT OF EYES WITH UNILATERAL CENTRAL SEROUS CHORIORETINOPATHY

Abstract

Purpose: To assess the visual function and its correlation with subfoveal choroidal thickness analysis in cases of unilateral inactive chronic central serous chorioretinopathy (CSC).

Methods: Cross-sectional observational study of cases with unilateral inactive chronic CSC. Visual function was evaluated by best-corrected visual acuity (BCVA), low contrast sensitivity and microperimetry (average threshold, AT; macular integrity, MI; and fixation stability, FS). Subfoveal choroidal thickness (SFCT) was measured by swept-source optical coherence tomography. An age and gender matched control group was used to compare the contrast sensitivity results.

Results: Fifteen patients (10 men, 5 women; mean age: 50.8 years) were included. The mean±SD BCVA was 0.17±0.17 logarithm of the minimum angle of resolution (logMAR) in eyes with CSC; 0.05±0.07 logMAR in the corresponding fellow eyes; and 0.04±0.05 in the control group. The mean axial length in eyes with CSC was 23.09+/-0.94 and 23.17+/-0.85 mm in the corresponding fellow eyes (p=0.865). The mean BCVA was significantly worse in eyes with CSC compared with the fellow eyes (p=0.007) and the control subjects (p=0.008). Low contrast sensitivity measured 0.78±0.15 in eyes with CSC; 0.51±0.18 in the corresponding fellow eyes; and 0.37±0.10 in the control eyes. The mean low contrast sensitivity values were significantly decreased in eyes with CSC compared with the fellow eyes (p=0.008) and the control group (p<0.001). In addition the mean low contrast sensitivity was also significantly decreased in the fellow eyes compared with the control group (p=0.02). With regards to the microperimetry results, MI and AT showed statistically significant differences between eyes with CSC and the corresponding fellow eyes (p=0.005 and p=0.002, respectively), whereas FS was not different between groups (p=0.33). The mean SFCT measured 360.8+/-98.24 microns in eyes with CSC and 325.8+/-92.78 microns in the corresponding fellow eyes (p=0.16)

Conclusions: Patients with unilateral chronic CSC may have a significant decrease in BCVA, low contrast sensitivity and microperimetric scores in their affected eye. In addition, we found the asymptomatic fellow eyes to show a decrease in the low contrast sensitivity compared to both CSC symptomatic eyes and normal age-matched controls. No significant differences were found between the affected and unaffected eyes in SFCT.

Keywords: 642 perimetry • 452 choroid • 688 retina