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Alessandro Cutini, Serena Fragiotta, Leopoldo Spadea, Erika Rigoni, Mariella Salomone, Michela Marcelli, Enzo M Vingolo; Normal values and repeatibility of bivariate contour ellipse area (BCEA) with Microperimeter Mp-1.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):169.
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To evaluate age-stratified normal bivariate contour ellipse area (BCEA) and repeatability using MP-1 microperimetry.
130 eyes of 130 healthy volunteers (age range: 20-80 years) were enrolled. All subjects had a logMAR acuity ≤ 0.0 without ocular pathologies on a complete ophthalmological examination. Fixation stability was quantified by calculating the BCEA obtained during a 30 second fixation test. A 2° red cross was used as fixation target. BCEA (deg2) was normalized by logarithmic transformation (Shapiro-Wilk test, p<0.05). Statistical analysis was performed using linear regression analysis and Pearson’s correlation for comparisons in all the 3 BCEA standard deviations (SD). All patients were then stratified by decade of life and a 2-way analysis of variance (ANOVA) followed by a Bonferroni post-hoc test was performed. Statistical significance was set at P <0.05.
There was no significant differences between eyes (I-III SD, P=0.16 and II SD, P=0.13) and sex (ISD, P=0.15 and II-III SD, P=0.16). There was a positive relationship between age and logBCEA (Pearson: r=0.29, P=0.001 for each SD). Linear regression analysis showed a significant increase in logBCEA with increasing age (P=0.004) for each SD. Regression analysis showed that BCEA decreased of 0.007 deg2 per year of age in the I SD. The age-stratified analysis showed significant differences between groups (ANOVA, I-II-III SD P=0.03). Intraclass correlation coefficients (ICC) calculated in the 3 standard deviation (SD) were 0.84 (95% confidence interval [CI], 0.52, 0.96, P<0.001) both in the I and III SD and 0.83 (95%CI, 0.96,7.10, P<0.001) in the II SD.
BCEA is a fast and simple technique to quantify fixation stability. This study provide the first normative age-matched database of BCEA, but also the factors that may influenced fixation stability in normal subjects. These findings can help the clinicians to correctly interpret the BCEA results. Finally, BCEA has a good test-retest reliability.
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