Purchase this article with an account.
Corinne Kostic, Sylvain Crippa, Catherine Martin, Randy H Kardon, Yvan Arsenijevic, Aki Kawasaki; Pupil responses to selective wavelength (colored) light stimulation in healthy and retinal degenerate mice. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1726.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Different light stimulus conditions were used to characterize the pupillary light reflex (PLR) in different mouse models.
Sv129 mice, Rho-/- and CNGA3-/- were subjected to short stimuli of increasing intensity of red and blue light alternatively. The PLR was recorded using the A2000 Neuroptics system. Maximal contraction amplitudes as well as recovery phase were compared between the different models.
In wild type mice, increasing intensity of blue light produced prolongation of the pupil contraction and a distinctive change in the pupil response waveforms, particularly post-stimulus recovery. Additionally the duration of dark adaptation influenced both amplitude and recovery of the PLR. In comparison, Rho-/- mice showed decreased pupil responses to all blue and red light stimuli except the highest intensity blue stimulus. Pupil responses of CNGA3-/- to blue or red light were similar to those of wild type mice.
Loss of photoreceptors differentially affects the PLR to light stimuli of different wavelengths and intensity.
This PDF is available to Subscribers Only