April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Visual Outcomes and Adverse Events in Diabetic Macular Edema Treated with VEGF Inhibitors-A Systematic Review
Author Affiliations & Notes
  • Karim Diab
    Ophthalmology, Western University, London, ON, Canada
  • Swati Chavda
    Ophthalmology, Western University, London, ON, Canada
  • Nathan Gorfinkel
    Ophthalmology, Western University, London, ON, Canada
  • William Hodge
    Ophthalmology, Western University, London, ON, Canada
    Epidemiology & Biostatistics, Western University, London, ON, Canada
  • Brad Dishan
    Medical Library, St. Joseph's Health Care, London, ON, Canada
  • Hargurinder Singh
    Ophthalmology, Western University, London, ON, Canada
    Epidemiology & Biostatistics, Western University, London, ON, Canada
  • Footnotes
    Commercial Relationships Karim Diab, None; Swati Chavda, None; Nathan Gorfinkel, None; William Hodge, None; Brad Dishan, None; Hargurinder Singh, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 1759. doi:
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      Karim Diab, Swati Chavda, Nathan Gorfinkel, William Hodge, Brad Dishan, Hargurinder Singh; Visual Outcomes and Adverse Events in Diabetic Macular Edema Treated with VEGF Inhibitors-A Systematic Review. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1759.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

VEGF Inhibitors are being used as part of the standard of care for diabetic macular edema. We did a systematic review to assess the overall efficacy and side effects of these agents for this condition.

 
Methods
 

Relevant literature was obtained using an exhaustive search from the Medline, Biosis, CINAHL, Cochrane and Web of Science databases. Grey literature that consisted of lectures, seminars and conferences was also retrieved. The results were then inserted into EPPI, the systematic review program. Duplicates were then removed using EPPI after a bibliographic record was made. Literature was then passed through two levels of screening followed by a data extraction level. Papers had to be included after each level of screening in order for data to be extracted from them. EPPI records whether a publication is included or excluded after each level of screening.

 
Results
 

24 studies treating 3992 eyes were retrieved. 83% of studies recorded an improvement in mean macular thickness ranging from an average of 16 to 194 microns. 93% of studies recorded an improvement of central vision. 14 cases of endophthalmitis have been reported (0.35%) and 39 cases of retinal detachment (0.98%). 105 cases of vitreous hemorrhage have been reported (2.6%)

 
Conclusions
 

VEGF inhibitor treatment for diabetic macular edema shows consistently positive results with few side but potentially serious effects.

 
Keywords: 462 clinical (human) or epidemiologic studies: outcomes/complications • 688 retina • 499 diabetic retinopathy  
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