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Gernot Roessler, Wilfried Mokwa, Bernd Sellhaus, Babac Mazinani, Peter Walter; Biocompatibility of Biochemically Modified Surfaces as a Fixation Concept for Epiretinal Stimulator Arrays. Invest. Ophthalmol. Vis. Sci. 2014;55(13):1833.
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© ARVO (1962-2015); The Authors (2016-present)
To prove the biocompatibility of biochemical fixation procedures for epiretinal stimulators as an alternative to the conventional fixation using retinal tacks
Polyimide microstructures were coated with different protein configurations by immobilizing laminin peptide composites onto the surface. Implantation was performed in rabbits including vitrectomy and the positioning of the structures onto the retinal surface. Following an observation period of three months the eyes were enucleated for histopathological examination.
Clinical examination during observation period show tight contact of the devices. Following enucleation HE staining revealed minor alteration of retinal tissue, showing a moderate degree of cystic disaggregation but with with good preservation of retinal cell layers’ integrity. In immunhistochemistry, slightly increased staining of Mueller cells suggests mild glial cell activation, while inflammatory cells are absent as in normal retina.
We demonstrated that basically a tight contact of the modified microstructures with the retinal surface could be achieved. The surgical interventions for implantation and explantation as well as the visual prosthesis itself do not produce any significant inflammatory effects in the retinal tissues. The findings suggest for the device to be sufficiently safe from a histopathologic point of view as to be further examined clinically.
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