April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Conjunctival Microvascular Hemodynamics in Sickle Cell Retinopathy
Author Affiliations & Notes
  • Ali Kord Valeshabad
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Justin Wanek
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Ruth Zelkha
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Jennifer I Lim
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Nicole Camardo
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Bruce Ira Gaynes
    Department of Veteran Affairs, Loyola University, Chicago, IL
  • Mahnaz Shahidi
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Footnotes
    Commercial Relationships Ali Kord Valeshabad, None; Justin Wanek, None; Ruth Zelkha, None; Jennifer Lim, None; Nicole Camardo, None; Bruce Gaynes, None; Mahnaz Shahidi, Pending Patent for EyeFlow Technology (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 194. doi:
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    • Get Citation

      Ali Kord Valeshabad, Justin Wanek, Ruth Zelkha, Jennifer I Lim, Nicole Camardo, Bruce Ira Gaynes, Mahnaz Shahidi; Conjunctival Microvascular Hemodynamics in Sickle Cell Retinopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):194.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine alterations in bulbar conjunctival microvascular hemodynamics in sickle cell retinopathy (SCR) eyes conditional on the presence of focal macular thinning (FMT).

Methods: Spectral domain optical coherence tomography (SD-OCT) and conjunctival microcirculation imaging were performed in 23 subjects (eyes) diagnosed with SCR. Retinal thickness maps were generated from 19 raster SD-OCT B-scans centered on the fovea, and mean retinal thickness measurements were calculated in 9 Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Eyes were assigned to one of two groups (with or without FMT) based on evaluation of the retinal thickness maps. From conjunctival microcirculation image sequences, venule diameter and axial blood velocity were measured in multiple venules in each eye by customized image analysis software. Average venule diameter and axial blood velocity values were derived for each eye.

Results: Mean age, hematocrit, sickle cell hemoglobin type, and median retinopathy stage score did not significantly differ between the with and without FMT groups (P ≥ 0.1). Retinal thickness in the parafoveal and perifoveal temporal subfields were significantly lower in eyes with FMT as compared to eyes without FMT (P = 0.04) . Venule diameters in eyes with FMT (20 ± 5 µm; N = 12) and eyes without FMT (21 ± 4 µm; N = 11) were similar (P = 0.7). Venule axial blood velocity in eyes with FMT (0.48 ± 0.20 mm/s) was significantly lower than in eyes without FMT (0.72 ± 0.29 mm/s) (P = 0.03).

Conclusions: Conjunctival venular blood velocity is lower in SCR subjects with FMT compared to subjects without FMT. Assessment of conjunctival microvascular hemodynamic properties may have potential value in gauging retinal ischemia.

Keywords: 474 conjunctiva • 550 imaging/image analysis: clinical • 688 retina  
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