April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Dynamic retinal vessel reaction to flickering light is changed in chronic hemodialysis patients
Author Affiliations & Notes
  • Konstantin E Kotliar
    Biomedical Engineering, Aachen University of Applied Sciences, Juelich, Germany
  • Christoph Schmaderer
    Nephrology, Technische Universität München, Munich, Germany
  • Susanne Tholen
    Nephrology, Technische Universität München, Munich, Germany
  • Arno Schmidt-Trucksaess
    Institute of Exercise and Health Sciences, Basel University, Basel, Switzerland
  • Ines M Lanzl
    Ophthalmology, Technische Universität München, Munich, Germany
  • Ieva Sliesoraityte
    Institut de la Vision, Paris, France
  • Uwe Heemann
    Nephrology, Technische Universität München, Munich, Germany
  • Marcus Baumann
    Nephrology, Technische Universität München, Munich, Germany
  • Footnotes
    Commercial Relationships Konstantin Kotliar, None; Christoph Schmaderer, None; Susanne Tholen, None; Arno Schmidt-Trucksaess, None; Ines Lanzl, None; Ieva Sliesoraityte, None; Uwe Heemann, None; Marcus Baumann, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 197. doi:https://doi.org/
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      Konstantin E Kotliar, Christoph Schmaderer, Susanne Tholen, Arno Schmidt-Trucksaess, Ines M Lanzl, Ieva Sliesoraityte, Uwe Heemann, Marcus Baumann; Dynamic retinal vessel reaction to flickering light is changed in chronic hemodialysis patients. Invest. Ophthalmol. Vis. Sci. 2014;55(13):197. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Retinal vessel response to flicker was shown to be altered in glaucoma, hypertension, diabetes mellitus and other ocular and systemic diseases. Chronic hemodialysis patients are usually multimorbid and show structural and functional vascular alterations. Whether the dynamic reaction to flicker stimulation in retinal vessels is changed in these patients is investigated.

 
Methods
 

Retinal arterial and venous reaction to flicker stimulation was examined by Dynamic Vessel Analyzer (DVA, IMEDOS Systems) in 123 hemodialysis patients (age 63,9 ± 14,8 years old) and in 25 medically validated healthy volunteers of similar age (58,7 ± 6,4 years old) and gender distribution. After baseline assessment of 50 s monochromatic rectangular flicker stimulation (530-600 nm, 12,5 Hz, 20 s) was applied 3 consecutive times. Parameters of dynamic vascular response were assessed and analyzed independent from the commercial DVA software.

 
Results
 

In most subjects fast vessel dilation compared to baseline was observed. There were a number of abnormal individual reactions in hemodialysis patients. Values of basic parameters of dynamic retinal vessel reaction in the examined groups are presented in the table. [mean±std. deviation (range)].

 
Conclusions
 

Functional retinal arterial and venous reaction to flicker stimulation differs significantly in hemodialysis patients compared to healthy subjects of the same age and gender. In average the magnitude of the vascular reaction is similar but the reaction is significantly delayed both in arteries and in veins. Since dynamic retinal vessel analysis provides a direct non-invasive assessment of microcirculatory damage, it would allow for practical and task-oriented risk stratification in dialysis patients.

  
Keywords: 688 retina • 464 clinical (human) or epidemiologic studies: risk factor assessment • 550 imaging/image analysis: clinical  
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