April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The Effect of Oxygen Treatment on Retinal Vessel Oxygen Saturation in Severe Chronic Obstructive Pulmonary Disease.
Author Affiliations & Notes
  • Thorunn Scheving Eliasdottir
    Ophthalmology, University of Iceland / Landspítali University Hospital, Reykjavik, Iceland
    Anesthesiology, University of Iceland / Landspitali University Hospital, Reykjavik, Iceland
  • Sveinn H Hardarson
    Ophthalmology, University of Iceland / Landspítali University Hospital, Reykjavik, Iceland
  • David Bragason
    Ophthalmology, University of Iceland / Landspítali University Hospital, Reykjavik, Iceland
  • Einar Stefansson
    Ophthalmology, University of Iceland / Landspítali University Hospital, Reykjavik, Iceland
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 200. doi:
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      Thorunn Scheving Eliasdottir, Sveinn H Hardarson, David Bragason, Einar Stefansson; The Effect of Oxygen Treatment on Retinal Vessel Oxygen Saturation in Severe Chronic Obstructive Pulmonary Disease.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):200.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To estimate the effects of oxygen therapy on retinal vessel oxygen saturation in patients with chronic obstructive pulmonary disease (COPD).

 
Methods
 

The Oxymap T1 retinal oximeter (Oxymap ehf., Reykjavik, Iceland) is based on a fundus camera and analysis software. It simultaneously captures images of the retinal vessels at 570 nm and 600 nm wavelengths for calculation of hemoglobin oxygen saturation. Eleven patients with severe COPD (stage 3 and 4) on long term oxygen treatment were included in the study. Mean oxygen saturation in retinal arterioles and venules of the right eye was measured during breathing of their daily supplemental oxygen and ambient air. Mean oxygen saturation of retinal arterioles was compared with finger pulse oximetry and radial artery oxygen saturation, the latter only during ambient air breathing.

 
Results
 

Oxygen saturation (%) in retinal arterioles and venules of right eye (n=10) and finger was significantly increased during oxygen breathing compared with ambient air breathing (see table). Arteriovenous difference was not significantly different between ambient air breathing and supplemental oxygen breathing. The figure illustrates mean oxygen saturation (%) of retinal arterioles, radial artery and finger (n=10) after breathing ambient air for 10 minutes. Oxygen saturation in retinal arterioles was 88±5% compared with 92±4% in radial artery (P= 0.07, paired t test) and 91±3% in finger (P=0.34).

 
Conclusions
 

Oxygen therapy increases oxygen saturation of retinal arterioles and venules in patients with severe COPD. The retinal arteriovenous difference is unaffected by the oxygen therapy. Oxygen saturation measurements are not statistically different between retinal oximetry, peripheral pulse oximetry and radial arterial blood gas analysis.

 
 
Table. Oxygen saturation (%) in retinal vessels and finger with and without oxygen therapy. All values are mean ± standard deviation. AV-difference: Arteriovenous difference. P value: Bonferroni post test, one way ANOVA. (CI:95% Confidence Intervals).
 
Table. Oxygen saturation (%) in retinal vessels and finger with and without oxygen therapy. All values are mean ± standard deviation. AV-difference: Arteriovenous difference. P value: Bonferroni post test, one way ANOVA. (CI:95% Confidence Intervals).
 
 
Figure. Oxygen saturation in retinal arterioles, radial artery and finger in 10 patients with COPD. Each dot represents mean oxygen saturation (%) after breathing ambient air for 10 minutes. The bars indicate mean ± SD.
 
Figure. Oxygen saturation in retinal arterioles, radial artery and finger in 10 patients with COPD. Each dot represents mean oxygen saturation (%) after breathing ambient air for 10 minutes. The bars indicate mean ± SD.
 
Keywords: 688 retina • 635 oxygen • 550 imaging/image analysis: clinical  
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