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Everardo Hernandez-Quintela, Nallely Ramos Betancourt, Alejandra Gonzalez-Dibildox, Manuel Ramirez; Diagnostic performance of electrical ocular surface resistance for dry eye disease. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2009.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the diagnostic performance of electrical ocular surface resistance (EOSR) for dry eye disease.
Thirty consecutive patients (30 eyes) were asked to complete an evaluation of dry eye signs and symptoms by the Ocular Surface Disease Index (OSDI) questionnaire, corneal staining with fluorescein, tear-film breakup time, and Schirmer’s test with anesthesia. EOSR was measured with two microelectrodes applied on the ocular surface. A total of 19 dry eye patients vs. 11 Non dry eye control group were compared. Mean age was 40.27 +/- 15.28 years old, 23 patients (76.7%) were female. Intra and inter-observer agreement were also analyzed.
Mean EOSR for normal subjects was 191 +/- 12K Ohms and 260 +/- 146K Ohms for the dry eye patients. Seven cases with Sjogren syndrome showed a significantly higher EOSR (363 +/- 196 K Ohms). EOSR correlated significantly with dry eye severity grade symptoms (OSDI, r = 0.53). Intra-observer Intraclass Correlation Coefficient was 0.92 (95%CI, 0.81 - 0.95) and for inter-observer analysis was 0.67 (95% CI, 0.30 - 0.84).
The present study found a higher EOSR in patients with severe dry eye compared with healthy controls. Testing EOSR might be an effective alternative objective diagnostic tool for dry eye disease.
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