April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Risk factors for corneal endothelial cell loss after cataract surgery in eyes with pseudoexfoliation syndrome
Author Affiliations & Notes
  • Yumi Hasegawa
    Miyata eye Hospital, Miyakonozyo, Japan
  • Ryohei Nejima
    Miyata eye Hospital, Miyakonozyo, Japan
  • Yosai Mori
    Miyata eye Hospital, Miyakonozyo, Japan
  • Toshihiro Sakisaka
    Miyata eye Hospital, Miyakonozyo, Japan
  • Keiichiro Minami
    Miyata eye Hospital, Miyakonozyo, Japan
  • Kazunori Miyata
    Miyata eye Hospital, Miyakonozyo, Japan
  • Tetsuro Oshika
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships Yumi Hasegawa, None; Ryohei Nejima, None; Yosai Mori, None; Toshihiro Sakisaka, None; Keiichiro Minami, None; Kazunori Miyata, None; Tetsuro Oshika, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2037. doi:
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      Yumi Hasegawa, Ryohei Nejima, Yosai Mori, Toshihiro Sakisaka, Keiichiro Minami, Kazunori Miyata, Tetsuro Oshika; Risk factors for corneal endothelial cell loss after cataract surgery in eyes with pseudoexfoliation syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2037.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: It has been reported that the presence of pseudoexfoliation syndrome (PES) is associated with a greater risk of corneal endothelial cell density (ECD) loss after cataract surgery, but there has been no study on its risk factors. We investigated the risk factors for ECD loss after phacoemulsification and intraocular lens implantation in eyes with PES.

Methods: Clinical records of 106 eyes of 86 patients with PES who had undergone cataract surgery from June 2010 through May 2013 were retrospectively reviewed. ECD was examined preoperatively and 3 months postoperatively with a specular microscope. Aqueous flare intensity was measured postoperatively with laser flare mater. Subjects were divided into two groups, i.e., group A (ECD loss > 5.0 %) and group B (ECD loss ≤ 5.0 %), and the influences of following factors were evaluated using unpaired t-test or Fisher's exact probability test; age, preoperative ECD, mydriatic pupil diameter, cataract grade (Emery-Little classification), presence of glaucoma or diabetes mellitus, preoperative anterior chamber depth (ACD), axial length, operation time, phacoemulsification time, postoperative intraocular pressure (1 day), and aqueous flare intensity (1 day, 1 week, 3 months).

Results: The pre- and post-operative ECDs were 2477.8 ± 320.2 and 2405.9 ± 346.2 cells/mm2, respectively, and mean ECD loss was 2.9 ± 5.9 %. There was 27 (25.5%) eyes in group A, in which ECD loss was significantly associated with shorter preoperative ACD (P = 0.011), longer phacoemulsification time (P = 0.015) and higher flare intensity 1 week after surgery (P = 0.040).

Conclusions: It was demonstrated that preoperative ACD, phacoemulsification time, and postoperative flare intensity are risk factors for greater EDC loss after cataract surgery in eyes with PES. It was suggested that corneal endothelium was damaged by surgical invasion caused by phacoemulsification.

Keywords: 479 cornea: clinical science • 481 cornea: endothelium  

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