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Ramin Khoramnia, Romain De Cock, Ingo Lieberwirth, Mark Whiting, Martin Emesz, Gerd Auffarth; Analysis of opacified hydrophilic IOLs after DSAEK. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2057.
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We report about the findings in opacified IOLs after DSAEK using light and scanning electron microscopy as well as x-ray spectroscopy.
Seven hydrophilic IOLs with opacification after DSAEK have been evaluated in this ongoing analysis so far. The explanted IOLs were cut in half. One half was stained (Alizarin red and von Kossa) and examined using light microscopy. The other half was examined using scanning electron microscopy. The composition of the deposits was analyzed by means of x-ray spectroscopy.
Macroscopically, all IOLs showed opacifications mostly in the center of the optic. In all IOLs, light and scanning electron microscopy revealed numerous fine, granular, crystalline-like deposits below the anterior surface of the IOL. These deposits caused an elevation of the surface of the IOL. X-ray spectroscopy could prove the deposits to consist of calcium and phosphate. Examination of the posterior surface did not reveal deposits in any of the lenses.
The calcification of hydrophilic IOLs only occurs rarely. However, the injection of intracameral gas during DSAEK seems to increase the risk for IOL opacification. Granular deposits below the anterior surface of the IOLs can be responsible for such a decrease in visual acuity that patients require IOL exchange.
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