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Daisuke Muramatsu, Hideyuki Kishida, Young-Joo Hong, Yoshiaki Yasuno, Takuya Iwasaki, Hiroshi Goto, Masahiro Miura; Three dimensional non-invasive vascular imaging of retinal vascular occlusion by optical coherence angiography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):212.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the retinal vascular occlusion with Doppler optical coherence angiography (OCA).
We prospectively examined 30 eyes of 29 patients with retinal vascular occlusion, including two eyes of branch retinal artery occlusion (BRAO), 18 eyes of branch retinal vein occlusion (BRVO), and 10 eyes of central retinal vein occlusion (CRVO) were investigated. 1060 nm swept-source Doppler optical coherence tomography (OCT) was used for non-invasive vascular imaging. The scanning range was 6.0 x 6.0 mm on the retina with 256 A-scans × 2048 B-scans, and scanning speed was 100,000 A-scan/s. High sensitive vascular image was obtained by calculating a squared power of the phase resolved Doppler signal obtained from two A-lines in two successive B-scans. From the three dimensional vascular image (Doppler OCA), we calculated retinal OCA image and choroidal OCA image, and evaluated three dimensional vascular architecture at retinal vascular occlusion.
In Doppler OCA images. Dilatation and tortuosity of the retinal vessels at obstructed area were clearly detected in eyes with BRVO and CRVO. Shunt vessels at optic disc were detected in 7 of 10 eyes with CRVO. These shunt vessels were located on the surface of the optic discs. In the two eyes with BRAO, defect of blood perfusion at occluded area were clearly detected in Doppler OCA. In one eye, restoring blood flow at 6 weeks after onset was detected in retinal OCA image. These Doppler OCA findings for retinal vascular occlusion were corresponded well with the fluorescein angiography images.
Doppler OCA is useful for evaluation of the retinal vascular changes. Doppler OCA assists non-invasive assessment of retinal vascular occlusion
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