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Sowmya Srinivas, Ou Tan, Shaung Wu, Muneeswar Gupta Nittala, David Huang, Rohit Varma, Srinivas R Sadda; Doppler Fourier-domain optical coherence tomography measured Retinal blood flow in Chinese American adults: The Chinese American Eye Study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):214.
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© ARVO (1962-2015); The Authors (2016-present)
To measure total retinal blood flow (TRBF) in normal, healthy adult Chinese Americans using Doppler Fourier-domain optical coherence tomography (FD-OCT).
Two hundred sixty-six normal, healthy Chinese American adults who were a part of the population-based Chinese American Eye Study (CHES) underwent a complete eye examination and Doppler OCT imaging using a standardized, double circular scan protocol consisting of eight circumpapillary circles which transected all major blood vessels entering/exiting the optic nerve head. Scans were then imported into a Doppler OCT of Retinal Circulation (DOCTORC) grading software, to calculate total retinal blood flow and other vascular parameters.
266 eyes of 266 participants were evaluated. The mean age of the study participants was 57.4 ± 5.6 (range: 50−82) years. The mean TRBF was 49.6 ± 10.9 (range: 30.3 - 79.8). Superior retinal hemisphere blood flow (25.60 ± 6.70 µl/min) was greater than inferior retinal hemisphere blood flow (24.01 ± 7.68 µl/min, P = 0.006). The mean blood flow velocity was 15.21 ± 3.05 mm/s. TRBF was lower in older persons compared to those who were younger (r = -0.17, P = 0.006). TRBF was also lower in persons with longer axial length compared to those with shorter axial length (r = -0.34, P = <0.0001).
Normal Doppler OCT-derived total retinal blood flow varies in a Chinese American population. These observations provide normative data to assess the TRBF in persons with eye disease.
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