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Kaweh Mansouri, Tarek Shaarawy; Assessment of sleep stages and relationship to intraocular pressure patterns using a contact lens sensor. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2165.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate whether information from a contact lens sensor for 24-h monitoring of intraocular pressure (IOP) patterns can be used to distinguish sleep stages. We further hypothesized that IOP patterns may be higher in the rapid eye movement (REM) phase.
12 healthy subjects underwent simultaneous ambulatory 24-h monitoring of IOP patterns using a contact lens sensor (CLS; Triggerfish, Sensimed AG, Switzerland) and sleep monitoring using a validated wireless system (WS; ZEO, Newton, MA, USA) that collects electrophysiological signals from the forehead with a single bi-polar channel. The CLS measures ocular dimensional changes at the corneo-scleral junction that are assumed to be related to IOP changes. The WS distinguishes 4 sleep stages: wake, light sleep, deep sleep, REM. Intraclass correlation coefficients (ICC) were calculated for comparison of CLS and WS-derived sleep stages.
Data on both IOP and sleep stages could be obtained in 10 subjects (mean age 42 ± 10.2 years; 60% women). Four different patterns of CLS-data could be distinguished during sleep: high-frequency sinusoidal pattern, low-frequency sinusoidal pattern, and irregular pattern. The irregular pattern correlated well with the WS-derived REM stage (ICC=0.91), while the other two CLS stages did not correlate well with WS sleep stages (ICC=0.47). IOP patterns during CLS-derived REM stages were higher than during non-REM sleep stages (128 ± 52 mV vs. 108 ± 42; p=0.044).
Results show a good agreement between CLS and WS recordings of REM sleep. This work further supports a possible use of combined sleep and IOP pattern monitoring in glaucoma patients.
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