April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Spectral-domain Optical Coherence Tomography with Split-Spectrum Amplitudinal Decorrelation Angiography: A New Way to Detect Retinal Vascular Anomalies without Dye Injection
Author Affiliations & Notes
  • Albert Lin
    Department of Ophthalmology, Univ of Mississippi Medical Center, Jackson, MS
  • Matthew Olsen
    Department of Ophthalmology, Univ of Mississippi Medical Center, Jackson, MS
  • Jody Watkins
    Department of Ophthalmology, Univ of Mississippi Medical Center, Jackson, MS
  • Ching Jygh Chen
    Department of Ophthalmology, Univ of Mississippi Medical Center, Jackson, MS
  • Footnotes
    Commercial Relationships Albert Lin, None; Matthew Olsen, None; Jody Watkins, None; Ching Chen, Optovue, Inc. (C), Optovue, Inc. (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 217. doi:
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      Albert Lin, Matthew Olsen, Jody Watkins, Ching Jygh Chen; Spectral-domain Optical Coherence Tomography with Split-Spectrum Amplitudinal Decorrelation Angiography: A New Way to Detect Retinal Vascular Anomalies without Dye Injection. Invest. Ophthalmol. Vis. Sci. 2014;55(13):217.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Spectral-domain optical coherence tomography (SD-OCT) using a split-spectrum amplitudinal decorrelational angiography (SSADA) algorithm allows for a novel way to assess retinal micro-circulation in 3D without using an intravenous contrast agent. Our study compares images of age-related macular degeneration (ARMD) with occult choroidal neovascularization (CNV) and retinal pigment epithelial detachment (RPED), and non-proliferative diabetic retinopathy (NPDR) with capillary nonperfusion using SSADA and fluorescein angiography (FA) to demonstrate the capabilities of this software.

 
Methods
 

FA imaging was obtained with an Ophthalmic Imaging Systems Winstation XP camera (Sacramento, CA). OCT images were obtained at 70 kHz A-scans per second using the Optovue Avanti RTVue XR OCT system (Fremont, CA). Prototype software using SSADA algorithms constructed SD-OCT angiography of the retinal microvasculature. The software then reconstructed the retinal and choroidal microvasculature in 3D, with the ability to isolate vasculature and circulation in individual layers of customized height in the retina and choroid.

 
Results
 

Imaging from SD-OCT angiography and FA were compared. In a patient with ARMD, SD-OCT angiography visualized the RPED and CNV well, especially the network of occult CNV. In a patient with NPDR, SD-OCT angiography demonstrated capillary non-perfusion better than FA.

 
Conclusions
 

SSADA provides detailed SD-OCT angiography of retinal pathology that shows promise of noninvasive angiography comparable with FA and a potentially deeper understanding of retinal and choroidal diseases.

 
 
Top left: FA imaging of a patient with ARMD with RPED and occult CNV. Top center: close-up view of FA, with RPED demonstrated by the green arrow and occult CNV by the red arrow. Top right: SD-OCT angiography imaging using SSADA software visualizing the RPED (green arrow) and the CNV (red arrows). Note the detailed fan-like network of vessels with a possible feeder vessel highlighted by the far right red arrow. Bottom: SD-OCT image of the retina.
 
Top left: FA imaging of a patient with ARMD with RPED and occult CNV. Top center: close-up view of FA, with RPED demonstrated by the green arrow and occult CNV by the red arrow. Top right: SD-OCT angiography imaging using SSADA software visualizing the RPED (green arrow) and the CNV (red arrows). Note the detailed fan-like network of vessels with a possible feeder vessel highlighted by the far right red arrow. Bottom: SD-OCT image of the retina.
 
 
Top left: FA imaging of a patient with NPDR. Top center: close-up view of FA. Top right: SD-OCT angiography imaging with microaneurysm highlighted by blue arrow, and capillary non-perfusion better visualized by SD-OCT angiography highlighted by the yellow boxes. Bottom: SD-OCT image of the retina.
 
Top left: FA imaging of a patient with NPDR. Top center: close-up view of FA. Top right: SD-OCT angiography imaging with microaneurysm highlighted by blue arrow, and capillary non-perfusion better visualized by SD-OCT angiography highlighted by the yellow boxes. Bottom: SD-OCT image of the retina.
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 688 retina • 550 imaging/image analysis: clinical  
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