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Min Wang, Gezhi Xu; Diagnosing choroidal neovascularization with optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):224.
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© ARVO (1962-2015); The Authors (2016-present)
To observe and evaluate the images of optical coherence tomography (OCT) angiography for diagnosing choroidal neovascularization (CNV) in macular area.
RTVue XR (Optovue,Inc.,Fremont,CA) was used to obtain split-spectrum amplitude-decorrelation angiography (SSADA) image on CNV lesion in macular area. SSADA is an algorithm that has been used in OCT angiography. Wet age-related macular degeneration and idiopathic CNV patients were recruited. All patients underwent spectral domain optical coherence tomography (SD-OCT), En Face OCT, indocyanine green angiography (ICGA) and fluorescein angiography (FA). SSADA scanning area was 3mmx3mm. SSADA scanning protocols were SSADA macula and SSADA choroid. En Face OCT protocol was MCT Retina.
SSADA image on CNV area clearly showed abnormal dilated blood vessels on choroid level and it matched the abnormal dilated choroidal blood vessel network on ICGA well. FA could not show the abnormality of choroid changes on CNV lesion. En Face OCT at retinal pigment epithelial reference level showed the contour of choroid blood vessels by OCT intensity. But SSADA image showed the changes of the retinal and choroidal circulation.
OCT angiography is a powerful technique to show the image of choroidal blood vessel network. As a non-invasive imaging technique, it provides important information on choroidal blood vessel network changes for evluating CNV. Combining En Face OCT, it could replace ICGA and FA for some extent when diagnosing CNV.
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