April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Lesion volume - a new dimension of corneal abnormality on AS-OCT
Author Affiliations & Notes
  • Simon Sheung Man Fung
    Cornea and External Disease, Moorfields Eye Hospital, London, United Kingdom
  • Dawn A Sim
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Andrew Keane
    NIHR Biomedical Research Centre for Opht, Moorfields Eye Hospital, London, United Kingdom
  • Adnan Tufail
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Mark R Wilkins
    Cornea and External Disease, Moorfields Eye Hospital, London, United Kingdom
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2467. doi:
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    • Get Citation

      Simon Sheung Man Fung, Dawn A Sim, Pearse Andrew Keane, Adnan Tufail, Mark R Wilkins; Lesion volume - a new dimension of corneal abnormality on AS-OCT. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2467.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To describe and evaluate the results of a novel technique, utilizing spectral domain anterior segment optical coherence tomography (SD-AS-OCT), to define the volume of corneal lesions.

 
Methods
 

Three patients with post-LASIK epithelial ingrowth, inactive herpes simplex stromal keratitis and vascularized herpes zoster stromal keratitis at Moorfield Eye Hospital were investigated with SD-AS-OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany). Anatomical layers of cornea (including epithelium, stroma, Descemet's membrane and endothelium), LASIK flap interface and lesions within corneal substance were manually delineated by custom image analysis software. Colour photographs were correlated with OCT findings.

 
Results
 

Different patterns of corneal lesions were revealed by SD-AS-OCT and the imaging allowed measurement of lesion size to be undertaken. Post-LASIK epithelial ingrowth was observed as sharply delineated hyperreflective lesions with surrounding oedematous corneal tissue at the flap interface, and reduced local epithelium thickness. Mean lesion height was 64.3μm, and volume 0.71mm3. Herpes simplex stromal keratitis appeared as a poorly defined, confluent lesion within the stroma, with a mean lesion height of 76.8μm and volume of 0.54mm3. In Herpes zoster corneal vascularization, hyperreflective linear scarring distorts the overlying Bowman's membrane, with a mean lesion height of 15.8μm and volume of 0.17mm3. In addition, corneal vessels adjacent and within the lesion could be detected on SD-AS-OCT images.

 
Conclusions
 

Quantitative measurements of lesion volume is a novel method to describe corneal lesions, and may be a useful tool in the management of other corneal disease.

 
 
Figure 1. AS-OCT image of corneal epithelial ingrowth after LASIK. A: raw image; B: segmented image with anatomical layers delineated. Lesion area is highlighted. Contiguous high density scans were used to calculate lesion volume.
 
Figure 1. AS-OCT image of corneal epithelial ingrowth after LASIK. A: raw image; B: segmented image with anatomical layers delineated. Lesion area is highlighted. Contiguous high density scans were used to calculate lesion volume.
 
Keywords: 550 imaging/image analysis: clinical • 479 cornea: clinical science  
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