April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Harmlessness of 1 mg cefuroxime intracameral injection at the end of cataract surgery
Author Affiliations & Notes
  • Germain Barreau
    C.H.U. Dupuytren, Limoges, France
  • Loïc Bourmault
    C.H.U. Dupuytren, Limoges, France
  • Juliette Delmas
    C.H.U. Dupuytren, Limoges, France
  • Jean-Paul Adenis
    C.H.U. Dupuytren, Limoges, France
  • Pierre-Yves Robert
    C.H.U. Dupuytren, Limoges, France
  • Footnotes
    Commercial Relationships Germain Barreau, None; Loïc Bourmault, None; Juliette Delmas, None; Jean-Paul Adenis, None; Pierre-Yves Robert, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2548. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Germain Barreau, Loïc Bourmault, Juliette Delmas, Jean-Paul Adenis, Pierre-Yves Robert; Harmlessness of 1 mg cefuroxime intracameral injection at the end of cataract surgery. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2548.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: Intracameral 1mg cefuroxime injection at the end of cataract surgery is included in the good practice in France and a lot of countries. Few studies have shown a macular toxicity for high doses of cefuroxime in particular in a case of dilution error for exemple. This study has the purpose to question if there is or not a macular toxicity with 1mg.

Methods: We propose a study on 18, of simple cataract operated, eyes : by phakoemulsification, with the same surgeon, without particular surgical complications, and no posterior capsule rupture. Only patients with medium cataract and a normal macula were included in the study. A time-domain macular OCT was pre-operatively made, and then at 7 and 30 post-operative days. The principal criterion of judgement was the central macular thickness at 30 post-operative days.

Results: The average pre-operative central macular thickness was 209,11 +/- 29,44 microns (143-279), at 7 post-operative days the average was 214,44 +/- 28,42 microns (145-267), and at 30 post-operative days was 219,44 +/- 27,41 microns (145-253). The differences observed between the pre and post-operative values were not significant.

Conclusions: These results show that at a dose of 1 mg, as an intracameral injection, and without posterior capsular rupture, cefuroxime does not significativly increase the central macular thickness. A study with a larger pool of patients would certainly confirm what the actual clinical practice lets us foresee.

Keywords: 445 cataract • 503 drug toxicity/drug effects • 585 macula/fovea  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.