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MELANTHO CHOULIDOU, Athanasios Vachtsevanos, Efi Karakosta, Antonia-Ioanna Vasilopoulou, Lazaros Kazantzidis, Dimitrios Tsakpinis, Alexandros Polychronakos; Prophylactic nepafenac in preventing postoperative macular edema after uneventful cataract surgery. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2549.
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© ARVO (1962-2015); The Authors (2016-present)
To Study the effectiveness of prophylactic nonsteroidal antiinflammatory drugs (NSAIDs) such as nepafenac, after uneventful cataract surgery on retina thickness and macular volume one month postoperatively.
We studied 116 eyes of patients with no ophthalmological history who underwent uneventful phacoemulsification surgery and intraocular lens implantation (IOL). Patients were randomized and divided into 2 subgroups A1 and A2. In the first subgroup A1 patients received topical nepafenac for a month beginning on the first postoperative day of surgery and administered one eye drop three times a day. In the second subgroup A2, no NSAIDs were administered. Retina thickness and macular volume were measured by Spectral cSLO / OCT (Opko) preoperatively and one month postoperatively.
Each study group included 58 patients. One month after surgery, the statistical analysis of the results showed no significant difference between the values of retina thickness and macular volume in both subgroups (A1, A2).
One month after uneventful cataract surgery and IOL implantation in patients with no ophthalmological history there was no significant difference in the values of retina thickness and macular volume among patients treated with nepafenac and those who were not treated with NSAIDs. Nepafenac was well tolerated with minimal side effects. In patients without any risk factors undergoing routine cataract surgery prophylaxis with NSAIDs is not recommended.
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