Purchase this article with an account.
Kazutaka Suzuki, Haruyoshi Toyoda, Naotoshi Hakamata, Naoko Kimura, Akihide Watanabe, Shigeru Kinoshita; Non-Invasive Detection for Parkinson’s Disease with Quantification of Minute and Subtle Eyelid Movements. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2566.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To develop a non-invasive diagnostic method for Parkinson's Disease (PD) using quantification of minute and subtle eyelid movements.
This study involves 20 PD patients and 25 age-matched healthy controls.Spontaneous blinking was recorded for 40 seconds.During the recording these subjects were guided to gaze in the straight-forward direction at a green fixation point.Figure 1 shows our blink measuring system built with the Intelligent Vision Sensor (IVS, HAMAMATSU PHOTONICS K.K.) which can take 1000 images per second and process the acquired images in real time.We extracted eyelid blink motion or speed exceeding 5mm/sec defined it as period of eyelid motion and then analyzed the times of blinks and amplitude.
The points at the center of a Figure 2 are the amplitude of the blink for each subject went.The left-hand side points express the healthy control's amplitude, and the right-hand side points express the PD patient's amplitude.The histogram on either side of Figure 2 shows the number of times for each amplitude range of the blink.Amplitude of blinks of PD patients took shorter than healthy controls (average 4.1, SD 2.4 mm vs. average 6.6, SD 2.5 mm : p<0.0001).In terms of number of occurrences of the blink, there was no significant difference between healthy controls (average 14.6, SD 9.3 times) and PD patients (average 12.7, SD 9.4 times).But, in PD patients, we could see that there are many short blinks which did not reach the lower eyelid completely during the blink motion.
Previous studies have shown that the blink amplitude was shortened and the blink rate was usually decreased in PD patients, although in some patients the blink rate was increased.As a result of evaluating the blink with high-speed and high-precision, we found suggestions that there was no change in the frequency of the blink in PD patients, although amplitude of the blink was shortened as with previous research.We think that the reason of this new suggestion is that the short blink wave, which is too short for measuring, could be measured by our measurement system.We expect that the quantification of fast and small blinks becomes possible by using this technique, and we can have early detection of PD and perform suitable medical treatment at an early stage.
This PDF is available to Subscribers Only