April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Impact of Anti-VEGF Therapy on the Photoreceptor Layer in Age-related Macular Degeneration: Short-term Evaluation Using Adaptive Optics Scanning Laser Ophthalmoscopy
Author Affiliations & Notes
  • Muneo Yamaguchi
    Kyushu University, Fukuoka, Japan
  • Shintaro Nakao
    Kyushu University, Fukuoka, Japan
  • Yuji Oshima
    Kyushu University, Fukuoka, Japan
  • Shigeo Yoshida
    Kyushu University, Fukuoka, Japan
  • Satomi Shiose
    Kyushu University, Fukuoka, Japan
  • Miho Yasuda
    Kyushu University, Fukuoka, Japan
  • Kumiko Kano
    Kyushu University, Fukuoka, Japan
  • Tatsuro Ishibashi
    Kyushu University, Fukuoka, Japan
  • Footnotes
    Commercial Relationships Muneo Yamaguchi, None; Shintaro Nakao, None; Yuji Oshima, None; Shigeo Yoshida, None; Satomi Shiose, None; Miho Yasuda, None; Kumiko Kano, None; Tatsuro Ishibashi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2609. doi:
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      Muneo Yamaguchi, Shintaro Nakao, Yuji Oshima, Shigeo Yoshida, Satomi Shiose, Miho Yasuda, Kumiko Kano, Tatsuro Ishibashi; Impact of Anti-VEGF Therapy on the Photoreceptor Layer in Age-related Macular Degeneration: Short-term Evaluation Using Adaptive Optics Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2609.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: The purpose of this study was to evaluate the impact of single anti-VEGF therapy on retinal photoreceptor in patients with wet age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) using Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO).

Methods: Fourteen eyes from fourteen patients with wet AMD or PCV were treated with intravitreal ranibizumab (IVR; seven patients) or intravitreal aflibercept (IVA; seven patients). All patients underwent a full ophthalmologic examination and imaging with prototype AO-SLO systems (Canon Inc) before and one month after anti-VEGF therapy. For each eye, images focused on the photoreceptor layer were recorded in an area apart from CNV lesion and a montage of AO-SLO images was created. Cone photoreceptors (cone density, cone spacing, and mosaic regularity of cone photoreceptors) in an area in the patients before and after anti-VEGF therapy were analyzed and compared.

Results: All patients had no apparent adverse events. The analysis of AO-SLO images showed that there was no significant difference between before and after anti-VEGF therapy in cone density (before/after ratio=1.02), mosaic regularity of cone photoreceptors (before: 31.9±2.9%, after: 32.0±3.1%, p=0.9), and cone spacing (before: 0.54±0.05%, after: 0.54±0.06%, p=0.9).

Conclusions: AO-SLO images showed that neither IVR nor IVA affect the photoreceptor cone densities, at least during the short term after the treatment.

Keywords: 688 retina  

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